Energy transfer dyes with enhanced fluorescence

Details Energy transfer dyes with enhanced fluorescence Energy transfer dyes with enhanced fluorescence

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 19/06 (2006.01) C07H 19/16 (2006.01) C07H 21/00 (2006.01) C09B 11/04 (2006.01) C09B 11/24 (2006.01) C09B 23/00 (2006.01) C09B 23/08 (2006.01) C09B 47/04 (2006.01) C09B 57/00 (2006.01) C09B 69/00 (2006.01) G01N 21/64 (2006.01)

Patent

CA 2203494

Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers facilitate the efficient transfer of energy between a donor an acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R21Z1C(O)R22R28 where R21 is a C1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z1 is either NH, sulfur or oxygen, R22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R28 includes a functional group which attaches the linker to the acceptor dye.

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