C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/08 (2006.01) A61K 39/395 (2006.01) C07K 16/00 (2006.01) C12P 21/04 (2006.01) G01N 33/574 (2006.01) C07H 21/04 (2006.01)
Patent
CA 2646329
The invention provides novel humanized antibody fragments that specifically bind prostate cell-surface antigen (PSCA), a protein which is overexpressed in variety of cancers, including prostate, bladder, and pancreatic cancer. Methods are provided for the use of the compositions of the invention for the treatment of cancer, diagnosis of cancer, to provide a prognosis of cancer progression, and for cancer imaging.
La présente invention concerne de nouveaux fragments d'anticorps humanisés qui se lient spécifiquement à l'antigène de surface de cellules prostatiques (PSCA), une protéine qui est surexprimée dans une multitude de cancers, y compris les cancer de la prostate, de la vessie et du pancréas. Cette invention concerne des méthodes d'utilisation des compositions de cette invention pour le traitement, le diagnostic et le pronostic de l'évolution du cancer, ainsi que pour l'imagerie du cancer.
Reiter Robert E.
Wu Anna M.
Fetherstonhaugh & Co.
The Regents Of The University Of California
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