C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 31/495 (2006.01) A61K 31/50 (2006.01) A61K 31/505 (2006.01) A61K 31/55 (2006.01) C07D 453/02 (2006.01) C07D 453/06 (2006.01) C07D 471/08 (2006.01) C12N 15/13 (2006.01)
Patent
CA 2048178
- 22 - ENGINEERED ANTIBODIES ABSTRACT QF THE DISCLOSURE A DNA library comprising the variable region of immunoglobulin light chains and a DNA library comprising the vari- able region of immunoglobulin heavy chains are obtained. A prokaryotic cell is transformed with plasmid expression vectors con taining one of said DNA libraries and the transformed cell is then infected with bacteriophage expression vectors containing the other of said DNA libraries. Infected and transformed cells express pro- teins. Proteins, including novel proteins, which bind to particular moieties can be selected by screening Fab proteins expressed by infected and transformed cells.
Caton Andrew J.
Curtis Peter J.
Rovera Giovanni
Weiner David B.
Caton Andrew J.
Curtis Peter J.
Rovera Giovanni
Sim & Mcburney
The Wistar Institute
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