Engineered antibodies with new world primate framework regions

Details Engineered antibodies with new world primate framework regions Engineered antibodies with new world primate framework regions

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2619244

The present invention provides an antibody or antigen-binding portion thereof having a variable region comprising at least two complementarity determining regions (CDRs) and at least three framework regions. The the framework regions are, or are derived from New World primate framework regions, and at least one of the CDRs is a non-New World primate CDR.

La présente invention concerne un anticorps ou une partie de liaison à l~antigène comportant une région variable comprenant au moins deux régions de détermination de complémentarité (CDR) et au moins trois régions de charpente. Les régions de charpente sont, ou sont dérivées des régions de charpente de primates du Nouveau Monde et au moins une des CDR est une CDR de primate n~appartenant pas au Nouveau Monde.

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