Engineered antibody constant domain molecules

Details Engineered antibody constant domain molecules Engineered antibody constant domain molecules

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) C07K 16/10 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2713281

Described herein are engineered antibody constant domain molecules, such as CH2 or CH3 domain molecules, comprising at least one mutation, or comprising at least one complementarity determining region (CDR), or a functional fragment thereof, engrafted in a loop region of the CH2 domain. The CH2 domain molecules described herein are small, stable, soluble, ex-hibit little to no toxicity and are capable of binding antigen.

La présente invention concerne des molécules modifiées du type anticorps, à domaine constant, telles que des molécules à domaine CH2 ou CH3, comprenant au moins une mutation, ou comprenant au moins une région de détermination de la complémentarité (CDR), ou un fragment fonctionnel de celles-ci, greffée dans une région de boucle du domaine CH2. Les molécules à domaine CH2 décrites ici sont petites, stables, solubles, présentent peu, voire aucune toxicité et sont capables de se lier à l'antigène.

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