C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/52 (2006.01) A61K 35/74 (2006.01) A61K 38/16 (2006.01) A61K 38/48 (2006.01) C07K 14/33 (2006.01)
Patent
CA 2758274
The present invention provides a novel modified BoNT/E catalytic domain and methods of use thereof. In one embodiment, the light chain residue 224, or a residue corresponding to residue 224, of the modified BoNT/E catalytic domain has been altered to be aspartic acid or glutamic acid. The modified catalytic domain cleaves SNAP23 but does not cleave SNAP29 or SNAP47, providing novel methods of treating diseases including without limitation, asthma, CF, chronic obstructive pulmonary, gastric acid efflux and inflammation, immune disorders with a cytokine component or cancers with a cytokine component.
Cette invention concerne un nouveau domaine catalytique BoNT/E modifié et des procédés pour l'utiliser. Dans un mode de réalisation, le résidu de chaîne légère 224, ou un résidu correspondant au résidu 224, du domaine catalytique BoNT/E modifié a été remplacé par un résidu acide aspartique ou acide glutamique. Le domaine catalytique modifié clive SNAP23 mais ne clive pas SNAP29 ou SNAP47, offrant ainsi de nouvelles méthodes pour traiter des maladies comprenant, sans caractère limitatif, l'asthme, la mucoviscidose, la pneumopathie obstructive chronique, le reflux gastrique et l'inflammation, les troubles immuns ayant une composante cytokine ou les cancers ayant une composante cytokine.
Barbieri Joseph T.
Chen Sheng
Mcw Research Foundation Inc.
Smart & Biggar
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