Engineered cells expressing multiple immunomodulators and...

Details Engineered cells expressing multiple immunomodulators and... Engineered cells expressing multiple immunomodulators and...

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) C12N 5/0783 (2010.01) A61K 35/12 (2006.01) A61K 38/20 (2006.01) A61P 35/00 (2006.01) C12N 5/10 (2006.01) C12N 15/00 (2006.01) C12N 15/861 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) C12N 15/24 (2006.01)

Patent

CA 2739902

This invention relates to the field of therapeutics. Most specifically invention provides methods of generating in vitro engineered immune cells conditionally expressing interleukin-12 (IL- 12) and one or more immunomodulators under the control of a gene expression modulation system in the presence of activating ligand and uses for therapeutic purposes in animals.

Linvention concerne le domaine de la thérapeutique. Linvention concerne de manière plus spécifique des cellules immunes modifiées in vitro exprimant de manière conditionnelle une interleukine-12 (IL- 12) et un ou plusieurs immunomodulateurs sous le contrôle dun système de modulation dexpression génique en présence dun ligand dactivation. Linvention concerne également des cellules modifées à des fins thérapeutiques pour les animaux.

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