Engineered cleavage half-domains

Details Engineered cleavage half-domains Engineered cleavage half-domains

C - Chemistry, Metallurgy

12

N

C12N 9/22 (2006.01) C12N 15/10 (2006.01) C12N 15/55 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2651494

Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence.

La présente invention concerne des demi-domaines résultant de clivage par génie génétique, des polypeptides de fusion comprenant des demi-domaines, des polynucléotides codant ces demi-domaines et protéines de fusion, ainsi que des cellules comprenant ces polynucléotides et/ou protéines de fusion. L'invention concerne aussi des procédés d'utilisation de ces polypeptides et polynucléotides, notamment pour un clivage ciblé d'une séquence génomique.

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