C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/85 (2006.01) C12N 5/0784 (2010.01) A61K 35/30 (2006.01) C12N 5/10 (2006.01) C12N 15/24 (2006.01) C12N 15/867 (2006.01) C12Q 1/00 (2006.01) G01N 33/543 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2702058
This invention provides the field of therapeutics. Most specifically present invention provides methods of generating in vitro engineered dendritic cells conditionally expressing interleukin-12 (IL- 12) under the control of a gene expression modulation system in the presence of activating ligand and uses for therapeutic purposes in animals including human.
L'invention concerne le domaine de la thérapeutique. Plus spécifiquement, la présente invention porte sur des procédés de génération de cellules dendritiques synthétisées in vitro exprimant de façon conditionnelle l'interleukin-12 (IL-12) sous le contrôle d'un système de modulation de l'expression génique en présence d'un ligand d'activation et sur des utilisations à des fins thérapeutiques chez des animaux dont l'homme.
Braughler J. Mark
Kumar Prasanna
Okada Hideho
Storkus Walter J.
Intrexon Corporation
Mbm Intellectual Property Law Llp
University Of Pittsburgh Of The Commonwealth System Of Higher Ed
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