Engineered scfv against bovine herpes virus type i

Details Engineered scfv against bovine herpes virus type i Engineered scfv against bovine herpes virus type i

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 31/22 (2006.01) A61P 37/04 (2006.01) C07K 14/03 (2006.01) C07K 16/08 (2006.01) C12N 15/63 (2006.01) G01N 33/569 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2693137

The present disclosure describes a single chain variable fragment (scFv) that binds BHV-1 virus com-prising a light chain variable region, a linker and a heavy chain variable region. The disclosure also describes nucleic acid molecules encoding the scFv molecules, methods and uses thereof for treating or neutralizing BHV-1 infection and diagnostic methods, agents and kits thereof.

La présente invention porte sur un fragment variable à chaîne unique (scFv) qui se lie au virus BHV-1 comprenant une région variable à chaîne légère, un lieur et une région variable à chaîne lourde. L'invention porte également sur des molécules d'acide nucléique codant pour les molécules scFv, sur leurs procédés et utilisations pour le traitement ou la neutralisation d'une infection par le BHV-1 et sur des procédés de diagnostic, des agents et des coffrets de celui-ci.

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