Engraftment of immune-deficient mice with human cells

Details Engraftment of immune-deficient mice with human cells Engraftment of immune-deficient mice with human cells

C - Chemistry, Metallurgy

12

Q

358/23, 195/1.36

C12Q 1/00 (2006.01) A01K 67/027 (2006.01) A61K 35/14 (2006.01) A61N 5/00 (2006.01) C12N 5/08 (2006.01) C12Q 1/02 (2006.01) A61N 5/10 (2006.01)

Patent

CA 1341451

A process for transplanting into an immunodeficient mouse, which is deficient in T-cells and B-cells, human cells to form a chimeric mouse is provided. The transplanted human cells proliferate and thereby permit in vivo study of the human cells. The human cells are isolated from a human tissue source. The process comprises: i) irradiating an immunodeficient mouse deficient in T-cells and B-cells with radiation to condition the mouse for transplant; ii) transplanting into the irradiated mouse, the isolated human cells; and iii) continuing to grow the mouse to proliferate the human cells in and permit the human cells to spread in the mouse, to provide thereby a chimeric mouse incorporating the human cells in appropriate murine tissue.

614825

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