Enhanced activation of natural killer cells using an nk cell...

Details Enhanced activation of natural killer cells using an nk cell... Enhanced activation of natural killer cells using an nk cell...

A - Human Necessities

61

K

A61K 31/4045 (2006.01) A61K 31/417 (2006.01) A61K 35/14 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 38/21 (2006.01) A61K 38/44 (2006.01) A61K 45/06 (2006.01) C12N 5/08 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2196756

An improved method for the prevention of the inactivation of natural killer (NK) cells and the enhanced activation of NK cells in the presence of monocytes using a combination of a natural killer cell activator and a compound effective to inhibit the production or release of intracellular hydrogen peroxide, or a hydrogen peroxide scavenger, is disclosed. The method is useful, for example, in the treatment of solid tumors, metastases and viral infection.

Procédé amélioré servant à empêcher l'inactivation de cellules tueuses naturelles (NK) et activation amplifiée desdites cellules en présence de monocytes au moyen d'une combinaison d'un activateur de cellules tueuses naturelles et d'un composé servant à inhiber la production ou la libération de peroxyde d'hydrogène intracellulaire ou à épurer le peroxyde d'hydrogène. Ce procédé est efficace, par exemple, dans le traitement de tumeurs solides, de métastases et d'infections virales.

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