A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2542886
Formulations and methods of treating human patients suffering from a condition characterized by lymphoid cancer, autoimmune disease or B cell hyperproliferation are disclosed, the treatment comprising administering (1) a cytotoxic amount of an antibody having specific binding for CDIM epitopes on a B cell, and (2) a cytotoxic agent, including a chemotherapeutic agent, radioactive isotope, cytotoxic antibody, immunoconjugate, ligand conjugate, immunosuppressant, cell growth regulator and/or inhibitor, toxin, or mixtures thereof, including agents that disrupt the cytoskeleton of B cells, particularly vinca alkaloids or colchicine.
L'invention porte sur des formulations et des procédés qui permettent de traiter des patients humains souffrant d'un état caractérisé par un cancer lymphoïde, une maladie auto-immune ou une hyperprolifération des lymphocytes B, lequel traitement consiste à administrer (1) une quantité cytotoxique d'un anticorps présentant une liaison spécifique aux épitopes CDIM sur un lymphocyte B, et (2) un agent cytotoxique comprenant un agent chimiothérapeutique, un isotope radioactif, un anticorps cytotoxique, un immunoconjugué, un conjugué de ligand, un immunosuppresseur, un inhibiteur et/ou régulateur de croissance cellulaire, une toxine ou des mélanges des éléments précités, y compris des agents qui brisent le cytosquelette des lymphocytes B, en particulier des vinca-alcaloïdes ou de la colchicine.
Bhat Neelima M.
Bieber Marcia M.
Sanders Martin E.
Teng Nelson N.h.
Palingen Inc.
Smart & Biggar
The Board Of Trustees Of The Leland Stanford Junior University
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