C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 17/00 (2006.01) A61K 39/395 (2006.01) B01D 15/26 (2006.01) C07K 1/16 (2006.01) C07K 16/00 (2006.01)
Patent
CA 2674356
This invention relates to the use of mixed mode chromatography for purification of at least one intact non-aggregated antibody from a mixture containing intact non-aggregated antibodies and undesirable materials, including fragmented or aggregated antibodies, host cell proteins, DNA, endotoxin, and/or virus. This invention further relates to the integration of such a method into a multi-step procedure with other fractionation methods for purification of antibodies suitable for in vivo applications.
L'invention concerne l'utilisation de la chromatographie en mode mixte afin de purifier au moins un anticorps intact non agrégé depuis un mélange contenant des anticorps intacts non agrégés et des matières indésirables, y compris des anticorps fragmentés ou agrégés, des protéines de cellules hôtes, de l'ADN, une endotoxine et/ou un virus. L'invention concerne, de plus, l'intégration du procédé dans un processus à étapes multiples comportant d'autres procédés de purification d'anticorps adéquats pour des applications in vivo.
Bio-Rad Laboratories Inc.
Smart & Biggar
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