A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/16 (2006.01) A61K 9/40 (2006.01) A61K 47/30 (2006.01) A61K 47/34 (2006.01)
Patent
CA 2748907
Improved compositions for tissue augmentation are provided. These compositions comprise an amount of crosslinked material sufficient to provide a melt temperature (T m) greater than 37C, wherein microparticles can be substantially uniformly dispersed and maintained at ambient room temperature as well as body temperature. Said compositions also provide high shear moduli, sufficient to effectively deliver microparticles into dense tissue and narrow intersticial spaces without significant disruption to the homogeneous distribution of microparticles within the solution. The provided compositions can be stored and shipped at room temperature without significant detriment to the material composition. Additional embodiments include a system for delivery of tissue augmentation materials and methods of manufacture thereof.
L'invention porte sur des compositions améliorées pour l'augmentation de tissu. Ces compositions comprennent une quantité de matériau réticulé suffisante pour fournir une température de fusion (Tm) supérieure à 37°C, les microparticules pouvant être dispersées de manière sensiblement uniforme et maintenues à la température ambiante ainsi qu'à la température corporelle. Lesdites compositions ont également des modules de cisaillement élevé, suffisants pour distribuer efficacement des microparticules dans un tissu dense et des espaces interstitiels étroits sans interruption significative de la distribution homogène des microparticules dans la solution. Les compositions de l'invention peuvent être stockées et expédiées à la température ambiante sans altération significative de la composition de la matière. Des modes de réalisation supplémentaires comprennent un système de distribution de matières d'augmentation de tissu et des procédés de fabrication de celles-ci.
Anderson Russell
Borden Ladner Gervais Llp
LandOfFree
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