Enhanced delivery of nucleic acid-based drugs

Details Enhanced delivery of nucleic acid-based drugs Enhanced delivery of nucleic acid-based drugs

A - Human Necessities

61

K

A61K 47/12 (2006.01) A61K 47/00 (2006.01) A61K 47/14 (2006.01) A61K 47/44 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2371095

The invention provides methods and associated compositions for enhancing the intracellular delivery of a nucleic acid-based drug, such as an oligonucleotide or gene, by administering the nucleic acid-based drug in combination or sequentially with an enhancer. Preferred enhancers are caprylic acid, capric acid or their pharmaceutically acceptable salts. The preferred route of administration is oral.

L'invention concerne des méthodes et des compositions associées permettant d'améliorer l'apport intracellulaire d'un médicament à base d'acide nucléique, tel qu'un oligonucléotide ou un gène, par l'administration de ce médicament à base d'acide nucléique avec un renforceur, de façon simultanée ou successive. De préférence, les renforceurs se présentent sous la forme d'acide caprylique, d'acide caprique ou de leurs sels pharmaceutiquement acceptables. De préférence, ce médicament est administré par voie orale.

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