Enhanced delivery via serpin enzyme complex receptor

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/87 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61P 11/00 (2006.01) A61P 25/00 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) A61P 31/04 (2006.01) A61P 31/12 (2006.01) A61P 31/14 (2006.01) A61P 31/18 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 9/64 (2006.01) C12N 15/88 (2006.01) A61K 38/12 (2006.01)

Patent

CA 2391348

Serpin enzyme complex receptors are used as targets for therapeutic drugs in the lungs and brain tissue. Any lung or brain disease and any therapeutic drug can be targeted to the lung or brain by use of ligands which specifically bind to the receptors. Complexes for delivery may include proteins, pharmacological agents, or nucleic acids, as well as carrier molecules, and ligands for the receptors. The ligands can be coupled directly to the therapeutic agent or to a carrier molecule which binds to the therapeutic agent.

L'invention concerne des récepteurs du complexe enzyme inhibiteur de la sérine protéase, qui sont utilisés comme cibles pour des médicaments thérapeutiques dans les tissus pulmonaires et cérébraux. Toute maladie pulmonaire ou cérébrale et tout médicament thérapeutique peuvent être ciblés sur les poumons ou le cerveau au moyen de ligands qui se lient de manière spécifique aux récepteurs. Les complexes destinés à être administrés peuvent comprendre des protéines, des agents pharmacologiques ou des acides nucléiques, ainsi que des molécules porteuses et des ligands destinés aux récepteurs. Les ligands peuvent directement être couplés à l'agent thérapeutique ou à une molécule porteuse qui se lie à l'agent thérapeutique.

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