A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/445 (2006.01) A61K 31/13 (2006.01) A61K 31/19 (2006.01) A61K 31/28 (2006.01) A61K 47/12 (2006.01) A61N 1/30 (2006.01)
Patent
CA 2252899
Improved electrotransport of therapeutic agents which include agent cations and polybasic anionic counter-ions is provided. Improved electrotransport is obtained by treating the therapeutic agent with a multivalent metal compound of the formula (MX) where M is a metallic cation having a valency of at least +2 and is reactive with the polybasic anionic counter-ion and X is a pH- increasing anion. Reduction in species which compete with the therapeutic agent for electrotransport delivery into the patient is obtained.
Cette invention se rapporte à un électrotransport perfectionné d'agents thérapeutiques comportant des cations constituant les agents proprement dits et des contre-ions anioniques polybasiques. On parvient à perfectionner l'électrotransport en traitant l'agent thérapeutique avec un composé métallique multivalent de formule MX où M est un cation métallique ayant une valence supérieure à 2 qui réagit avec le contre-ion anionique polybasique et X est un anion susceptible d'élever le pH. On parvient à une réduction des espèces qui sont en compétition avec l'agent thérapeutique pour être administrés audit patient par électrotransport.
Alza Corporation
Smart & Biggar
LandOfFree
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