Enhanced formulations of lamotrigine

Details Enhanced formulations of lamotrigine Enhanced formulations of lamotrigine

A - Human Necessities

61

K

A61K 31/53 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 9/50 (2006.01) A61K 47/12 (2006.01) A61K 47/32 (2006.01) A61K 47/34 (2006.01) A61K 47/38 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2598948

A once-a-day, extended-release formulation of lamotrigine, exhibiting a significantly similar release rate throughout the GI tract irrespective of the pH of the environment, is provided. The formulation comprises lamotrigine, an organic acid, a release enhancing polymer and a release controlling polymer. The use of the formulation for the treatment of the neurological disorders is also disclosed.

L'invention porte sur une formulation de lamotrigine à libération prolongée, à administrer une fois par jour, présentant une vitesse de libération significativement analogue dans tout le tractus gastro-intestinal indépendamment du pH de l'environnement. La formulation comprend de la lamotrigine, un acide organique, un polymère améliorant la libération et un polymère contrôlant la libération. L'invention porte également sur l'utilisation de la formulation pour le traitement des troubles neurologiques.

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