C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
195/43, 195/1.29
C12N 1/38 (2006.01) C07K 14/02 (2006.01) C12N 15/81 (2006.01) C12P 21/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2022108
10/FSC7 17894 TITLE OF THE INVENTION ENHANCED GROWTH AND EXPRESSION OF HETEROLOGOUS PROTEINS IN RECOMBINANT HOSTS CONTAINING MUTATIONS IN CELL WALL AND/OR PLASMA MEMBRANE BIOSYNTHESIS ABSTRACT OF THE DISCLOSURE A fermentation process as well as a medium for producing recombinant proteins in a host strain containing the desired mutation in cell wall and/or plasma membrane biosynthesis (e.g. mnn9) is disclosed. An example of such a strain is described in Merck's pending application Serial No. 202,764 filed June 3, 1988.
Kniskern Peter J.
Maigetter Robert Z.
Schulman Cheryl A.
Gowling Lafleur Henderson Llp
Kniskern Peter J.
Maigetter Robert Z.
Merck & Co. Inc.
Schulman Cheryl A.
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