Enhanced hiv-1 vaccines and methods for their use

A - Human Necessities – 61 – K

Patent

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A61K 39/21 (2006.01)

Patent

CA 2521174

ENHANCED HIV-1 VACCINES AND METHODS FOR THEIR USE ABSTRACT The present invention provides peptides and proteins for use in second generation HIV vaccines and as diagnostic tools in the treatment and control of HIV infection. The antiviral protection shown by compositions of the present invention has not been previously achieved with an HLA epitope-enhanced vaccine. These findings define a critical balance between MHC affinity and receptor crossreactivity required for effective epitope enhancement and also demonstrate construction and efficacy of such a component of a new generation vaccine.

La présente invention a trait à des peptides et des protéines destinés à être utilisés dans des vaccins VIH de deuxième génération et en tant qu'outils de diagnostic dans le traitement et le contrôle d'une infection par VIH. La protection antivirale que présentent les compositions de la présente invention n'a pas été réalisée précédemment avec un vaccin activé par épitope HLA. Ces découvertes définissent un équilibre critique entre l'affinité MHC et la réactivité croisée requise pour une activation d'épitope efficace et démontre également la construction et l'efficacité d'un tel constituant d'un vaccin de nouvelle génération.

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