Enhanced indolinone based protein kinase inhibitors

Details Enhanced indolinone based protein kinase inhibitors Enhanced indolinone based protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/404 (2006.01) A61K 31/5377 (2006.01)

Patent

CA 2610067

Alpha-hydroxy- omega-(2-oxo-indolylidenemethyl-pyrrole-3'-carbonyl) amino alkanoic acid and amide derivatives have enhanced and unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.

Selon l'invention, un acide alpha-hydroxy-oméga-(2-oxo-indolylideneméthyl-pyrrole-3'-carbonyl) amino alcanoïque et des dérivés amide présentent des propriétés médicamenteuses améliorées et inattendues en tant qu'inhibiteurs des protéines kinases et conviennent au traitement de troubles relatifs à des activités anormales de la protéine kinase, tels que le cancer.

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