Enhanced ocular neuroprotection/neurostimulation

Details Enhanced ocular neuroprotection/neurostimulation Enhanced ocular neuroprotection/neurostimulation

A - Human Necessities

61

K

A61K 38/13 (2006.01) A61P 27/02 (2006.01)

Patent

CA 2615990

An ocular method comprising non-systemic localized ocular administration of a pharmaceutically acceptable formulation and effective concentration of at least one neuro-stimulatory and/or neuro-protective macrolide or other agent for a duration sufficient to enhance viability, confer protection, and/or reduce degeneration of retinal neural cells; enhance corneal sensation and/or ameliorate, and/or prevent ocular scarring. The method is used in a patient having or at risk for developing glaucoma, retinitis pigmentosa, or another ocular neuro-associated disease.

L'invention concerne un procédé oculaire comprenant une administration oculaire localisée non-systémique d'une formulation pharmaceutiquement acceptable, et à une concentration efficace, d'au moins un macrolide neuro-stimulateur et/ou neuro-protecteur ou autre agent, pendant une durée suffisante pour améliorer la viabilité, conférer la protection et/ou réduire la dégénérescence des cellules neurales rétiniennes ; améliorer la sensation cornéenne et/ou améliorer et/ou prévenir une cicatrisation oculaire. Le procédé est utilisé chez un patient présentant un glaucome, ou risquant de développer un glaucome, une rétinite pigmentaire ou autre maladie oculaire neuro-associée.

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