Enhanced opening of abnormal brain tissue capillaries

Details Enhanced opening of abnormal brain tissue capillaries Enhanced opening of abnormal brain tissue capillaries

A - Human Necessities

61

K

A61K 38/16 (2006.01) A61K 38/04 (2006.01) A61K 38/17 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2309947

Improved compositions and methods for increasing permeability of abnormal brain tissue to pharmaceutical agents. Cyclic GMP specific phosphodiesterase inhibitors are combined with bradykinin or a bradykinin analog to provide enhanced permeability of brain capillaries which is limited to abnormal brain tissue. Neuropharmaceutical and neurodiagnostic agents introduced into the bloodstream are directed selectively to the abnormal brain tissue. The pharmaceutical preparation composed of bradykinin or a bradykinin analog and a cyclic GMP specific phosphodiesterase inhibitor may be administered either intravenously or directly into the carotid artery.

L'invention concerne des compositions et des procédés permettant d'augmenter la perméabilité du tissu cérébral anormal aux agents pharmaceutiques. Des inhibiteurs de la phosphodiestérase spécifique de l'acide guanylique cyclique sont combinés avec une bradykinine ou un analogue de bradykinine pour assurer une meilleure perméabilité des capillaires cérébraux qui est limitée au tissu cérébral anormal. Des agents neuropharmaceutiques et neurodiagnostiques introduits dans la voie sanguine sont dirigés sélectivement vers le tissu cérébral anormal. La préparation pharmaceutique renfermant une bradykinine ou un analogue de bradykinine et un inhibiteur de la phosphodiestérase spécifique de l'acide guanylique cyclique peut être administrée par voie intraveineuse ou directement dans l'artère carotide.

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