Enhanced phage display library of human vh fragments and...

Details Enhanced phage display library of human vh fragments and... Enhanced phage display library of human vh fragments and...

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) C12N 7/01 (2006.01)

Patent

CA 2384388

Phage display libraries are taught in which the recombinant phage population displays a plurality of potential binding fragments having preferred characteristics of solubility and/or intermolecular interaction. Also taught are methods of biasing display libraries to produce variants which more closely approximate the preferred characteristics of the parental binding fragment.

L'invention concerne des bibliothèques d'affichage de phages dans lesquelles la population de phages recombinants présente plusieurs fragments de liaison potentiels possédant des caractéristiques préférées de solubilité et/ou d'interaction intermoléculaire. L'invention concerne également des procédés de dépolarisation de bibliothèques d'affichage, afin de produire des variants, qui approchent au plus près des caractéristiques préférées du fragment de liaison parent.

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