Enhanced pharmacokinetic profile of hydrophobic substances

Details Enhanced pharmacokinetic profile of hydrophobic substances Enhanced pharmacokinetic profile of hydrophobic substances

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/70 (2006.01) A61K 31/395 (2006.01) A61M 37/00 (2006.01) A61N 1/30 (2006.01)

Patent

CA 2452321

A method for systemic administration of a hydrophobic substance to a mammal is disclosed. The method involves delivering the hydrophobic substance to the dermis of the mammal whereby improved systemic absorption is obtained compared to absorption produced upon delivering the substance subcutaneously by bolus administration.

L'invention concerne une méthode d'administration systémique d'une substance hydrophobe à un mammifère. Ladite méthode consiste à injecter la substance hydrophobe dans le derme du mammifère, obtenant ainsi une absorption systémique améliorée par rapport à l'absorption obtenue lorsqu'est délivrée la substance de manière sous-cutanée par administration par bolus.

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