Enhanced production of clotting factors by cryoprecipitation

Details Enhanced production of clotting factors by cryoprecipitation Enhanced production of clotting factors by cryoprecipitation

A - Human Necessities

61

K

A61K 35/16 (2006.01) A61L 24/10 (2006.01) C07K 1/30 (2006.01) C07K 14/745 (2006.01)

Patent

CA 2514158

The blood collection, processing and transfer by separation of discrete components containing additional citrate (at least about trisodium citrate 9% w/v) in one or other of collection or processing bag provides for enhanced yield and purity of cryoprecipitate. Inhibiting the activation or denaturation of blood components including blood cells and plasma proteins and with the removal of the activated and denatured components thereby improving safety and efficacy of end products. The inventive process is particularly suited to an improved extraction process to yield concentrated clotting factors from single donors or limited pools without use of chromatography. Following extraction the remaining cryoprecipitate can advantageously be formed into a fibrin fabric used in surgeries and in the treatment of wounds.

La collecte, le traitement et le transfert de sang par séparation de composants discrets contenant un supplément de citrate (au moins environ 9 % poids/vol de citrate de trisodique) dans un sachet de collecte et/ou de traitement permet d'améliorer le rendement et la pureté d'un cryoprécipité. Cette invention permet d'inhiber l'activation ou la dénaturation de composants sanguins tels que des cellules sanguines et des protéines de plasma et d'éliminer des composants activés et dénaturés, améliorant ainsi la sécurité et l'efficacité des produits finaux. Le procédé selon cette invention est notamment adapté à un processus d'extraction amélioré qui permet de produire des facteurs de coagulation concentrés à partir de donneurs simples ou de groupes limités, sans utiliser de chromatographie. Après extraction, le cryoprécipité résultant peut avantageusement être intégré sous forme de tissu de fibrine utilisé dans le domaine chirurgical et dans le traitement des plaies.

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