Enhanced production of proteins by cell culture

Details Enhanced production of proteins by cell culture Enhanced production of proteins by cell culture

C - Chemistry, Metallurgy

12

N

195/1.29, 195/12

C12N 1/38 (2006.01) C07K 14/435 (2006.01) C07K 14/52 (2006.01) C07K 14/61 (2006.01) C07K 16/00 (2006.01) C07K 16/06 (2006.01) C12N 5/12 (2006.01) C12N 5/16 (2006.01) C12N 9/00 (2006.01) C12N 9/72 (2006.01) C12P 21/00 (2006.01)

Patent

CA 1341367

Increased yields of proteins are obtained by culturing genetically engineered or hybridoma cells, which constitutively produce the proteins, in the presence of chemical agents which enhance production of the proteins. The agents are employed at concentrations which enhance production of the proteins but do not substantially decrease cell growth rate or significantly reduce cell viability. The agents include alkanoic acids and salts thereof. The proteins include recombinant proteins and immunoglobulins.

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