Enhanced resolution maldi tof-ms sample surface

H - Electricity – 01 – J

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H01J 49/04 (2006.01) G01N 1/28 (2006.01) H01J 49/16 (2006.01)

Patent

CA 2205040

A thin layer for sample analysis by matrix-assisted laser desorption mass spectrometry, comprising a matrix material in a supported dispersion wherein the support is a solid or is formed from a solid. The invention is also directed to a method of making a thin layer for sample analysis by matrix-assisted laser desorption mass spectrometry, the layer comprising a matrix-solid composition disposed upon a substrate, comprising the step of depositing a solution containing matrix, solid and solvent upon a spinning substrate at a deposition rate sufficient to allow evaporation of the solvent, thereby interspersing the matrix and support on the substrate in a thin layer. Enhanced mass resolution is described.

L'invention porte sur une couche mince servant à l'analyse par spectrométrie de masse à désorption laser assistée par matrice, dans laquelle la matrice est une dispersion sur support solide ou formé à partir d'un solide. L'invention porte également sur un procédé d'élaboration d'une couche mince pour l'analyse d'échantillons par spectrométrie de masse à désorption laser assistée par matrice où ladite couche comprend une composition matrice/solide déposée sur substrat obtenue par dépôt de la matrice, du solide et du solvant sur un substrat rotatif, à une vitesse de dépôt suffisante pour permettre l'évaporation du solvant de façon à imbriquer la matrice et le support sur le substrat en une couche mince. On obtient ainsi une résolution en masse améliorée.

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