Enhanced secretion of polypeptides

Details Enhanced secretion of polypeptides Enhanced secretion of polypeptides

C - Chemistry, Metallurgy

12

N

C12N 15/70 (2006.01) C07K 14/00 (2006.01) C07K 14/48 (2006.01) C12N 15/18 (2006.01) C12N 15/62 (2006.01) C12N 15/67 (2006.01)

Patent

CA 2185343

A signal peptide sequence and nucleic acids encoding this sequence which are useful for improving the secretion efficiency of NGF polypeptides are provided. Also provided is a method for preparing Met-less NGF polypeptides.

Sont décrits une séquence de peptides-signaux et des acides nucléiques encodant cette séquence, qui sont utiles pour améliorer l'efficacité de sécrétion des polypeptides du facteur de croissance des neurones (NGF). Est également décrit un procédé pour préparer des polypeptides NGF sans Met.

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