A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/355 (2006.01) A61K 9/10 (2006.01) A61K 31/337 (2006.01) A61K 47/16 (2006.01) A61P 35/00 (2006.01) A61P 39/00 (2006.01) A61P 39/06 (2006.01)
Patent
CA 2366884
The present invention provides a method for enhancing the delivery of antioxidant Vitamin E compounds to tissues, cells and subcellular sites (both in vivo and in vitro) and in particular to mitochondria, thereby increasing the antioxidative capacity of mitochondria. The Vitamin E compounds that are administered may be cleaved by cellular esterases to release antioxidant .alpha.-T, .beta.-T, .gamma.-T, and/or .delta.-T. Further, the administration of Vitamin E compounds may have a coordinate action with respect to treating tumors in that the intact, uncleaved form of the Vitamin E compound has antitumor activity while the cleaved form exerts antioxidant effects.
L'invention concerne une méthode destinée à améliorer l'apport de composés de vitamine E antioxydants à des tissus, à des cellules et à des sites infracellulaires (aussi bien in vivo qu'in vitro) et, en particulier, aux mitochondries, augmentant ainsi la capacité antioxydante de ces dernières. Les composés de vitamine E administrés peut être clivés par des estérases cellulaires de façon à libérer du .alpha.-T, .beta.-T, .gamma.-T et/ou du .delta.-T antioxydant. L'administration de composés de vitamine E peut en outre avoir une action coordonnée par rapport au traitement des tumeurs en ce que les composés, à l'état intact et non clivé, présentent une activité antitumorale tandis qu'à l'état clivé, ils ont des effets antioxydants.
Macrae & Co.
Washington State University Research Foundation
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