Enhanced transdermal transfer using ultrasound

Details Enhanced transdermal transfer using ultrasound Enhanced transdermal transfer using ultrasound

A - Human Necessities

61

M

A61M 37/00 (2006.01) A61K 9/00 (2006.01) A61K 41/00 (2006.01) A61N 1/32 (2006.01)

Patent

CA 2200984

Several means for enhancing transdermal transport of drugs and analytes have been developed, including the use of low frequence ultrasound, chemical modifiers of permeability and/or cavitation, iontophoresis and/or electroporation (electric fields), pressure and/or vacuum (physical enhancers), and magnetic force fields. Applications of low-frequency (approximately 20 KHz to 1 MHz) ultrasound enhances transdermal transport of drugs and measurements of the concentration of analytes in body fluids such as blood or lymph. Delivery can be further enhanced or controlled through the use of carriers for the drugs, such as liposomes or microparticles, using a wide range of ultrasound frequency ranges and intensities. The microparticles are preferably small, and may have surfaces with increased hydrophilicity or lipophilicity to further enhance transport.

Plusieurs moyens permettant d'améliorer le transport transdermique de médicaments et de substances à analyser ont été mis au point, à savoir l'utilisation d'ultrasons basse fréquence, de modificateurs chimiques de la perméabilité et/ou de la cavitation, l'iontophorèse et/ou l'électroporation (champs électriques), la pression et/ou le vide (moyens physiques) et des champs magnétiques. La production d'ultrasons basse fréquence (de 20 KHz à 1 MHz environ) améliore le transport transdermique de médicaments et la mesure de la concentration de substances à analyser dans les liquides organiques tels que le sang ou la lymphe. Ce transport peut être encore amélioré ou mieux régulé par l'emploi de véhicules pour les médicaments, tels que les liposomes ou les microparticules, si l'on fait appel à une vaste plage d'intensités et de fréquences dans les ultrasons. Les microparticules sont de préférence de petite taille. On peut rendre leur surface plus hydrophile ou plus lipophile, ce qui en améliorera encore le transport.

Affiliated with

Also associated with

Rating

Enhanced transdermal transfer using ultrasound does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Enhanced transdermal transfer using ultrasound, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Enhanced transdermal transfer using ultrasound will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1713625