Enhanced vaccines

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07K 16/42 (2006.01) C07K 16/46 (2006.01)

Patent

CA 2348756

The invention relates to methods and materials involved in the treatment and prevention of various diseases such as infections and IgE-related diseases. Specifically the invention relates to methods and materials that can be used to vaccinate a mammal against specific self or non-self antigens. The material comprises e.g. a complex of a self and an immunogenic non-self part of an antigen e.g. the Fc part of IgE. Also claimed are complexes of polypeptides having at least a stretch of five amino acids of similar structure in common. The effects of IgE within a mammal can be reduced by reducing the amount of total and receptor bound IgE in the mammal. In addition, the invention provides vaccine conjugates, immunogenic polypeptides and corresponding nucleic acid molecules and host cells and methods for making these conjugates, polypeptides and nucleic acid. Further, the invention provides an IgE vaccine that induces an anti-self IgE response in a mammal.

L'invention concerne des procédés et matières impliqués dans le traitement et la prévention de différentes maladies, telles que des infections et des maladies liées aux immunoglobulines E (IgE). L'invention concerne plus particulièrement les procédés et matières qui peuvent être utilisés pour vacciner un mammifère contre des antigènes autologues ou non autologues spécifiques. Par exemple, les procédés et matières décrits peuvent servir à réduire les effets des anticorps IgE chez un mammifère par la réduction de la quantité totale d'anticorps IgE liés au récepteur chez les mammifères. De plus, l'invention procure des conjugués de vaccins, des polypeptides immunogéniques, des molécules d'acide nucléique qui codent les polypeptides immunogéniques, les cellules hôtes contenant les molécules d'acide nucléique qui codent les polypeptides immunogéniques, et des procédés de production des conjugués de vaccins et de polypeptides immunogéniques aussi bien que les molécules d'acide nucléique qui codent les polypeptides immunogéniques. En outre, l'invention fournit un vaccin IgE qui induit une réponse IgE non autologue chez un mammifère.

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