Enhanced wound coverage to enhance wound healing

Details Enhanced wound coverage to enhance wound healing Enhanced wound coverage to enhance wound healing

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 9/127 (2006.01) A61K 9/70 (2006.01) A61K 31/7088 (2006.01) A61K 38/18 (2006.01) A61K 38/27 (2006.01) A61K 38/30 (2006.01) A61L 15/32 (2006.01) A61L 15/40 (2006.01) A61L 15/44 (2006.01) A61L 26/00 (2006.01)

Patent

CA 2377371

The present invention describes the incorporation of liposomal gene constructs directly into a wound to further improve wound repair, or into wound coverage and/or closure materials to enhance the functionality of the material. The present invention further describes the use of human fetal membranes (e.g., amnion) enhanced with the liposomal gene therapy as a wound coverage material in full-thickness wound repair. The enhanced fetal membranes or enhanced cadaver skin have advantages over currently used materials lacking the liposomal gene construct and are an efficient and safe approach to improve clinical outcome in patients with burn injuries.

La présente invention concerne l'utilisation d'un liposome pour incorporer directement des gènes chimères dans une blessure afin d'en accélérer la guérison, ou dans un pansement et/ou un matériel de couverture pour améliorer la fonctionnalité de ce dernier. L'invention concerne en outre l'utilisation de membranes foetales humaines (p. ex. l'amnios) améliorées par traitement génique par liposome comme matériel de pansement destiné à soigner une blessure profonde. Les membranes foetales améliorées ou la peau de cadavre améliorée présentent des avantages par rapport aux matériels couramment utilisés qui sont dépourvus de gènes chimères enfermés dans un liposome, et constituent un moyen efficace et sûr d'améliorer le résultat clinique chez des patients souffrant de brûlures.

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