Enhancement of alcohol metabolism

Details Enhancement of alcohol metabolism Enhancement of alcohol metabolism

A - Human Necessities

61

K

A61K 31/191 (2006.01) A61P 25/32 (2006.01)

Patent

CA 2501543

D-glyceric acid has been found to enhance alcohol metabolism and thereby prevent adverse effects of alcohol consumption. D-glyceric acid is administered concurrently with alcohol, to accelerate the elimination of the alcohol from the body. D-glyceric acid is converted into D-glyceraldehyde and further into glycerol in reactions catalysed by NADH-aldehyde dehydrogenase and NADH-alcohol dehydrogenase complexes, which are produced in excess during alcohol oxidation, in the cells of alcohol-metabolising tissues. In these reactions, the NADH complexes become NAD-aldehyde dehydrogenase and NAD- alcohol dehydrogenase complexes. These complexes which in turn accelerate the oxidation of alcohol, which is paralleled by enhancement of acetaldehyde oxidation to metabolically harmless acetic acid. D-glyceric acid or its salt or ester is used for the manufacture of a pharmaceutical preparation for enhancing the metabolism of alcohol. A method of enhancing the metabolism of alcohol in a subject by administering said compounds an effective amount of D- glyceric acid or its salt or ester is disclosed. An oral or parenteral pharmaceutical preparation comprising said compounds is also disclosed.

L'acide D-glycérique augmente le métabolisme de l'alcool et permet ainsi d'empêcher les effets néfastes de la consommation d'alcool. L'acide D-glycérique est administré en même temps que l'alcool est pris, ce qui accélère l'élimination corporelle de l'alcool. Cet acide est transformé en D-glycéraldéhyde puis en glycérol dans des réactions catalysées par la NADH-aldéhyde déshydrogénase et par des complexes de NADH-alcool déshydrogénase complexes, produits en excès lors l'oxydation d'alcool dans les cellules des tissus métabolisant l'alcool. Dans ces réactions, les complexes du NADH deviennent des complexes de NAD-aldéhyde déshydrogénase et de NAD-alcool déshydrogénase. Ces complexes, qui à leur tour accélèrent l'oxydation d'alcool, avec en parallèle une augmentation de l'oxydation d'acétaldéhyde an acide acétique métaboliquement inoffensif. L'acide D-glycérique, un de ses sels ou esters est utilisé dans la fabrication d'un préparation pharmaceutique destinée à améliorer le métabolisme de l'alcool. Un procédé d'amélioration du métabolisme de l'alcool chez un sujet consiste à lui administrer ces composés. L'invention concerne aussi une préparation pharmaceutique orale ou parentérale contenant ces composés.

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