Enhancement of anti-androgenic activity by a combination of...

A - Human Necessities – 61 – K

Patent

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A61K 31/357 (2006.01) A61K 31/121 (2006.01) A61K 31/167 (2006.01) A61K 31/20 (2006.01) A61K 31/275 (2006.01) A61P 17/02 (2006.01) A61P 17/14 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2554025

The present invention includes novel methods and compositions for inhibiting or reducing steroid-dependent gene activation including the administration of at least two compounds that act different steps within a steroid receptor gene activation pathway. Preferred methods may include administering a first compound able to induce degradation of a steroid receptor and administering a second compound able to inhibit gene activation at a different step of the steroid receptor pathway. Steroid-dependent gene activation may be reduced or inhibited, modulated or controlled greater when the at least two of the compounds are administered in combination or together.

L'invention concerne des procédés et des compositions permettant d'inhiber ou de réduire l'activation de gène à dépendance stéroïde : administration d'au moins deux composés agissant à différentes étapes de trajet d'activation de gène de récepteur stéroïde. De préférence, les procédés peuvent consister à administrer un premier composé capable d'induire la dégradation de récepteur stéroïde et à administrer un second composé capable d'inhiber l'activation de gène à une étape différente du trajet de récepteur stéroïde. L'activation de gène à dépendance stéroïde peut être réduite ou inhibée, modulée ou contrôlée de façon renforcée lorsqu'au moins deux composés, comme indiqué ci-dessus, sont administrés en combinaison ou ensemble.

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