Enhancement of antimicrobial peptide activity by metal ions

Details Enhancement of antimicrobial peptide activity by metal ions Enhancement of antimicrobial peptide activity by metal ions

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61K 47/02 (2006.01)

Patent

CA 2263164

Provided are methods for maintaining or enhancing the antimicrobial activity of antimicrobial peptides, lytic peptides, and peptide-derived antibiotics by the use of metal ions. Also provided are pharmaceutical and other compositions comprising such peptides and/or at least one metal ion. Also provided are therapeutic and other methods for controlling the growth of undesirable or pathogenic microorganisms in various loci or milieu in, on, or outside the body employing these peptides and metal ions. Also provided are kits comprising containers containing a peptide and a metal ion(s), respectively.

La présente invention se rapporte à des procédés permettant de maintenir ou de faciliter l'activité antimicrobienne de peptides antimicrobiens, de peptides lytiques et d'antibiotiques dérivés de peptides au moyen d'ions métalliques. On décrit également des compositions pharmaceutiques et autres comprenant lesdits peptides et/ou au moins un ion métallique. On décrit aussi des procédés thérapeutiques et autres permettant, par l'emploi de ces peptides et ions métalliques, de freiner la croissance de micro-organismes indésirables ou pathogènes en plusieurs endroits ou dans divers milieux à l'intérieur ou à l'extérieur du corps, ou sur celui-ci. L'invention porte également sur des trousses comprenant des récipients contenant l'un, un peptide et l'autre, au moins un ion métallique.

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