Enhancement of b cell proliferation by il-15

Details Enhancement of b cell proliferation by il-15 Enhancement of b cell proliferation by il-15

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 38/20 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2583274

Compositions and methods for modulating the growth, proliferation, and/or differentiation of B-cells in the germinal center are disclosed, and include use of IL-15 inhibitors, antagonists, and agonists. The compositions and methods find use in treating B-cell-related disorders, including neoplasms of the B-cell lineage.

L'invention concerne des compositions et des procédés permettant de moduler la croissance, la prolifération, et/ou la différentiation des lymphocytes B dans le centre germinatif. Elle concerne également l'utilisation d'inhibiteurs de IL-15, d'antagonistes et d'agonistes. Ces compositions et procédés sont utiles dans le traitement de troubles associés aux lymphocytes B, y compris des tumeurs de la lignée de lymphocytes B.

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