C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/00 (2006.01) A61K 31/713 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2723716
This invention provides methods and compositions for screening of microRNA capable of modulating gene expression in the apoptotic pathway in the presence of HSP90 inhibitor. The use of miRNA for enhancing the activity of therapeutic agents not limited to HSP90 inhibitor is also disclosed. The diagnostic use of miRNA for predicting response to therapy not limited to therapeutic agents is also disclosed. A method for the identification and therapeutic application of small molecules which are modulators of these nucleic acids are also included in this application.
La présente invention concerne des procédés et des compositions pour le criblage de précurseurs ARN capables de moduler lexpression génique dans la voie apoptotique en présence dinhibiteur de HSP90. Linvention concerne également lutilisation de précurseurs ARN pour améliorer lactivité dagents thérapeutiques non limités à linhibition de HSP90. Linvention concerne également lutilisation diagnostique de précurseurs ARN pour prédire une réponse à une thérapie non limitée à des agents thérapeutiques. Un procédé pour lidentification et lapplication thérapeutique de petites molécules qui sont des modulateurs de ces acides nucléiques est inclus dans cette demande.
Desai Neil
Hwang Larn
Trieu Vuong
Abraxis Bioscience Llc
Ridout & Maybee Llp
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