Enhancement of hematopoietic stem cell survival

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 5/071 (2010.01) A61K 35/14 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2481406

A composition is disclosed that includes lin cells that are characterized as expressing CD31, CD34 and CD105, and not expressing c-kit, wherein the composition comprises fewer than 20% of lineage committed cells. Methods are disclosed for isolating CD31+CD34+CD45-CD105+c-kit-cells. Methods for reconstituting hematopoiesis using compositions including CD31+CD34+CD105+CD45- kit- cells are also disclosed.

L'invention concerne une composition qui comporte des cellules lin?-¿ qui expriment CD31, CD34 et CD105, mais qui n'expriment pas c-kit. Ladite composition comprend moins de 20 % de cellules déterminées pour une lignée. L'invention concerne des procédés permettant d'isoler des cellules CD31?+¿CD34?+¿CD45?-¿CD105?+¿c-kit?-¿, ainsi que des procédés permettant de reconstituer l'hématopoïèse grâce à des compositions comportant des cellules CD31?+¿CD34?+¿CD45?-¿CD105?+¿c-kit?-¿.

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