Enhancement of immunity by intranasal inoculation of il-12

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/39 (2006.01) A61K 39/02 (2006.01) A61K 39/12 (2006.01) A61K 39/145 (2006.01)

Patent

CA 2322337

The present invention relates to a method of enhancing an immune response to a pathogen in a host using intranasal administration of interleukin-12 (IL-12). In one embodiment, the present invention relates to a method of inducing an immune response to a pathogen in a host, which comprises administering intranasally to the host an effective amount of IL-12 and an antigen of the pathogen. In another embodiment, the present invention relates to a method of enhancing an immune response to a pathogen in a host, which comprises administering intranasally to the host an effective amount of IL-12 and an antigen of the pathogen. In a particular embodiment, the present invention relates to a method of inducing an immune response to a mucosal pathogen in a host, which comprises administering intranasally to the host an effective amount of IL-12 and an antigen of the pathogen. Also encompassed by the present invention is a method of inducing a Th1-like immune response to a pathogen in a host, comprising administering intranasally to the host an effective amount of IL-12 and an antigen of the pathogen. The present invention also relates to a method of enhancing a mucosal immune response to a pathogen in a host, which comprises administering intranasally to the host an effective amount of IL-12 and an antigen of the pathogen.

L'invention porte sur un procédé renforçant la réponse immunitaire à un agent pathogène par administration intra-nasale d'interleukine-12 (IL-12). Dans l'une de ses réalisations l'invention à trait à une méthode d'induction chez un hôte d'une réponse immunitaire à un agent pathogène par administration intra-nasale d'une dose efficace d'interleukine-12 et d'un antigène de l'agent pathogène. Dans une autre réalisation l'invention à trait à une méthode renforçant chez un hôte la réponse immunitaire à un agent pathogène par administration intra-nasale d'une dose efficace d'interleukine-12 et d'un antigène de l'agent pathogène. Dans une autre réalisation particulière l'invention à trait à une méthode renforçant chez un hôte la réponse immunitaire à un agent pathogène des muqueuses par administration intra-nasale d'une dose efficace d'interleukine-12 et d'un antigène de l'agent pathogène. L'invention porte également sur une méthode d'induction chez un hôte d'une réponse immunitaire du genre Th-1 à un agent pathogène par administration intra-nasale d'une dose efficace d'interleukine-12 et d'un antigène de l'agent pathogène.

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