C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) C07K 14/24 (2006.01) C07K 14/26 (2006.01) C12N 1/21 (2006.01) C12P 1/00 (2006.01) C12P 7/60 (2006.01)
Patent
CA 2417969
A method for enhancing a host cell's biosynthetic production of a desired compound derived from an at least partially intracellular pathway of said host cell is described. Such method comprises selecting a host cell that has an at least partially intracellular synthetic pathway which utilizes an extracellular substrate; increasing the transport of said extracellular substrate into said host cell while maintaining the integrity of the host cell, culturing the host cell to produce said extracellular substrate; and producing the desired compound. The transport of the substrate is increased by transforming into the host cell DNA encoding for one or more enzymes transporting the substrate into the host cell.
La présente invention concerne un procédé permettant de conforter la production biosynthétique d'une cellule hôte d'un composé attendu dérivé d'un chemin au moins partiellement intracellulaire de ladite cellule hôte. Ce procédé implique d'abord de sélectionner une cellule hôte disposant d'un chemin synthétique au moins partiellement intracellulaire utilisant un substrat extracellulaire. On augmente ensuite le transport dudit substrat extracellulaire aboutissant dans ladite cellule hôte tout en préservant l'intégrité de la cellule hôte, puis on met en culture la cellule hôte de façon à produire ledit substrat extracellulaire. Il ne reste plus qu'à produire le composé considéré. L'augmentation du transport substratique résulte de la transformation dans la cellule hôte d'ADN codant pour une ou plusieurs enzymes transportant le substrat jusque dans la cellule hôte.
Kumar Manoj
Valle Fernando
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Genecor International Inc.
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