A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 47/48 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2323210
A method for enhancing intracellular delivery of effector molecules is provided. The method involves modifying selected antibodies with biotin and streptavidin, conjugating these antibodies with an effector molecule, and delivering the conjugated effector to an intracellular target specifically recognized by the antibody.
L'invention concerne un procédé destiné à favoriser l'apport intracellulaire par des molécules effectrices. Ce procédé consiste à modifier certains anticorps à l'aide de biotine et de streptavidine, à conjuguer ces anticorps avec une molécule effectrice, et à apporter cet effecteur conjugué à une cible intracellulaire, spécifiquement reconnue par ledit anticorps.
Albelda Steven M.
Muzykantov Vladimir R.
Borden Ladner Gervais Llp
The Trustees Of The University Of Pennsylvania
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