A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/416 (2006.01) A61K 31/4162 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2460005
A method for enhancing learning and memory or treating amnesia. The method includes administrating to a subject in need thereof a compound of the formula (I) : each of Ar1, Ar2, and Ar3, independently, is phenyl, thienyl, furyl, or pyrrolyl ; each of R1, R2, R3, R4, R5, and R6, independently, is H, nitro, halogen, R, OH, OR, C(O)OH, C(O)OR, C(O)SH, C(O)SR, C(O)NH2, C(O)NHR, C(O)NRR', ROH, ,ROR', RSH, RSR', ROC(O)R'OH, NHR, NRR', RNHR', or RNR'R'', or R1 and R2 together, R3 and R4 together, or R5 and R6 together are ORO ; wherein each of R, R', and R'', independently is C1.sim.C6 alkyl ; and n is 1, 2, or 3. The compound is in an effective amount for enhancing learning and memory or treating amnesia.
L'invention a trait à un procédé permettant d'améliorer l'apprentissage et la mémoire, ou de traiter l'amnésie. Ledit procédé consiste à administrer à un sujet un composé de la formule (I), où Ar¿1?, Ar¿2?, et Ar¿3?, indépendamment, représentent phényle, thiényle, furyle, ou pyrrolyle ; R¿1?, R¿2?, R¿3?, R¿4?, R¿5? et R¿6?, indépendamment, représentent H, nitro, halogène, R, OH, OR, C(O)OH, C(O)OR, C(O)SH, C(O)SR, C(O)NH¿2?, C(O)NHR, C(O)NRR', ROH, ROR', RSH, RSR', ROC(O)R'OH, NHR, NRR', RNHR', ou RNR'R'' ; ou R¿1? et R¿2 ?pris ensemble, R¿3 ?et R¿4? pris ensemble, ou R¿5? et R¿6 ?pris ensemble, représentent ORO ; R, R' et R'', indépendamment, représentent un alkyle en C¿1?-C¿6? ; et n est 1, 2 ou 3. Ledit composé, en une dose efficace, permet d'améliorer l'apprentissage et la mémoire, ou de traiter l'amnésie.
Chien Wei-Lin
Fu Wen-Mei
Kuo Sheng-Chu
Lee Fang-Yuan
Liang Keng-Chen
Carlsbad Technology Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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