A - Human Necessities – 61 – N
Patent
A - Human Necessities
61
N
A61N 5/06 (2006.01)
Patent
CA 2301844
The efficacy of a plurality of PDT treatments following at least an initial PDT treatment is enhanced by increasing the neutrophil count of the patient substantially above a normal level. The increase in the neutrophil count leads to a more rapid removal of dead abnormal cells and stroma that have been destroyed, thereby enabling light administered in subsequent PDT treatments to more effectively reach and destroy still living abnormal cells on the surface of the tumor. The accelerated removal of dead tumor cells also enables a more accurate assessment of the treatment progress, since the actual tumor size should be more evident in image of the site. By enabling a tumor to be more rapidly destroyed by multiple PDT treatments, the risk of metastatic spread of abnormal cells away from the treatment site is also reduced.
Selon l'invention on accroît l'efficacité de plusieurs traitements PDT (thérapie photodynamique) suivant au moins un premier traitement PDT en augmentant le taux des neutrophiles du patient, afin de porter ce taux au-dessus d'un niveau normal. Cette augmentation du taux des neutrophiles conduit à un enlèvement plus rapide des cellules anormales mortes et stromas détruits, permettant ainsi à la lumière administrée lors de traitements PDT ultérieurs d'atteindre plus efficacement les cellules anormales, encore vivantes, et de les détruire, sur la surface de la tumeur. Cet enlèvement accéléré des cellules tumorales mortes permet également d'évaluer les progrès du traitement, étant donné que la taille réelle de la tumeur doit être plus apparente dans une image du site. En permettant la destruction plus rapide d'une tumeur, à l'aide de plusieurs traitements PDT, on diminue également le risque d'extension métastatique des cellules anormales, en dehors du site de traitement.
Light Sciences Corporation
Light Sciences Limited Partnership
Smart & Biggar
LandOfFree
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