Enhancement of macrolide penetration through human skin

Details Enhancement of macrolide penetration through human skin Enhancement of macrolide penetration through human skin

A - Human Necessities

61

F

A61F 13/00 (2006.01)

Patent

CA 2601694

The addition of a skin modifying agent to a macrolide having molecular weight between 500 and 1200 Daltons unexpectedly improves the delivery of the macrolide through human skin when compared to the drug mixed with alcohol alone. The skin modifying agent can be formulated with suitable excipients to form a lotion, ointment, cream, or gel for treating psoriasis and other skin disorders.

L'invention concerne l'ajout d'un agent de modification de la peau dans un macrolide dont le poids moléculaire est compris entre 500 et 1200 daltons permettant d'améliorer l'administration du macrolide dans la peau humaine, comparativement au médicament mélangé à de l'alcool uniquement. L'agent de modification de la peau peut être formulé au moyen d'excipients appropriés, afin de constituer une lotion, un onguent, une crème ou un gel permettant de traiter le psoriasis et d'autres troubles de la peau.

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