Enhancement of oligonucleotide inhibition of protein...

Details Enhancement of oligonucleotide inhibition of protein... Enhancement of oligonucleotide inhibition of protein...

C - Chemistry, Metallurgy

12

N

C12N 15/10 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C12N 1/36 (2006.01) C12N 7/04 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2166890

The invention features the use of a purified first targeted oligonucleotide in combination with either 1) a subtargeted oligonucleotide, 2) second targeted oligonucleotide, or 3) a non-targeted phosphorothioate oligonucleotide, to inbibit protein production of a targeted nucleic acid sequence, cell proliferation, and/or the multiplication of a foreign organism. The subtargeted oligonucleotide contains a truncated version of the targeted oligonucleotide.

L'invention concerne l'utilisation d'un premier oligonucleotide ciblé purifié conjointement avec 1) un oligonucléotide sous-ciblé, 2) un deuxième oligonucléotide ciblé, ou 3) un oligonucléotide de phosphorothioate non ciblé de manière à inhiber la production protéique d'une séquence d'acides nucléiques ciblée, la prolifération cellulaire et/ou la multiplication d'un organisme étranger. L'oligonucléotide sous-ciblé contient une version tronquée de l'oligonucléotide ciblé.

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