Enhancement of ribozyme catalytic activity by a neighboring...

Details Enhancement of ribozyme catalytic activity by a neighboring... Enhancement of ribozyme catalytic activity by a neighboring...

C - Chemistry, Metallurgy

12

N

C12N 15/10 (2006.01) A61K 31/70 (2006.01) C07H 21/04 (2006.01) C07K 14/16 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2117428

Methods are disclosed for increasing ribozyme catalytic activity without reducing specificity, which methods comprise contacting an RNA molecule with a ribozyme and a facilitator oligonucleotide. The present invention further provides compositions comprising a ribozyme and an effective amount of a facilitator oligonucleotide. Methods are also disclosed for reducing the concentration of Mg2+ and Mn2+ required by a ribozyme to catalytically cleave target RNA.

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