Enhancement of the action of anti-infective agents

A - Human Necessities – 61 – K

Patent

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Details

A61K 45/06 (2006.01) A61K 9/107 (2006.01) A61K 31/00 (2006.01) A61K 31/19 (2006.01) A61K 31/23 (2006.01) A61K 33/00 (2006.01) A61P 31/00 (2006.01)

Patent

CA 2416512

The invention provided a method of enhancing the action of a pharmaceutical agent selected from the group consisting of the group comprising antimicrobial agents, the anthelmintic agents and the anti-ectoparasitic agents, but excluding coal tar solution and H1-antagonist antihistamines, characterised in that the agent is formulated with an administration medium which comprises a solution of nitrous oxide gas in a pharmaceutically acceptable carrier solvent for the gas and which administration medium includes at least one fatty acid or ester or other suitable derivative thereof selected from the group consisting of oleic acid, linoleic acid, alpha- linolenic acid, gamma-linolenic acid, arachidonic acid, eicosapentaenoic acid [C20: 5w3], decosahexaenoic acid [C22: 60], ricinoleic acid and derivatives thereof selected from the group consisting of the C1 to C6 alkyl esters thereof, the glycerol-polyethylene glycol esters thereof and the reaction product of hydrogenated natural oils composed largely of ricinoleic acid based oils, such as castor oil with ethylene oxide.

L'invention concerne un procédé d'amélioration de l'action d'un agent pharmaceutique pouvant être un agent antimicrobien, anthelminthique et anti-ectoparasitique, à l'exclusion des antihistaminiques à solution de goudron de houille et H1-bloquants. La substance est formulée sur la base d'un milieu d'administration qui comprend une solution de gaz d'oxyde nitreux dans un solvant support physiologiquement acceptable pour le gaz. Le milieu d'administration comprend au moins un acide ou un ester gras ou autre dérivé correspondant approprié, pouvant être acide oléique, acide linoléique, acide alpha-linoléique, acide gamma-linoléique, acide arachidonique, acide éicosapentanoïque [C20: 5.omega.3], acide décosahexanoïque [C22: 6.omega.3], acide ricinoléique, et leurs dérivés, pouvant être esters d'alkyle C¿1-6? correspondants, esters de glycérol-polyéthylène glycol correspondants et le produit de la réaction entre des huiles naturelles hydrogénées renfermant essentiellement des huiles à base d'acide ricinoléique (par exemple, huile de ricin), d'une part, et de l'oxyde d'éthylène, d'autre part

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