Enhancement of the cellular immune response

C - Chemistry – Metallurgy – 12 – N

Patent

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167/104, 167/135

C12N 5/02 (2006.01) A61K 35/14 (2006.01) A61K 35/18 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 45/00 (2006.01) C07K 14/705 (2006.01) C12N 5/06 (2006.01)

Patent

CA 1335883

DTH-Effector T-cells expressing the CD5 and not the CD8 phenotype are primed with an antigen containing a specific tumor-associated carbohydrate determinant and are used to enhance the cellular immune response. Tumors have been inhibited by DTH-Effector cells expressing the CD5 and not the CD8 phenotype cells primed with such antigen con- taining a tumor-associated specific carbohydrate determi- nant, e.g., with epiglycanin and with synthetic T and Tn antigens. Either the DTH-Effector cells expressing the CD5 and not the CD8 phenotype, or those specific tumor-asso- ciated carbohydrate antigens directly, may be used for tumor prophylaxis and therapy.

541382

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